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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

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                                    FORM 8-K
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                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

      DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): SEPTEMBER 27, 2005

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                                 CRYOLIFE, INC.
             (Exact name of registrant as specified in its charter)
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               FLORIDA                              1-13165                           59-2417093
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    (State or Other Jurisdiction            (Commission File Number)                 (IRS Employer
          of Incorporation)                                                       Identification No.)


              1655 ROBERTS BOULEVARD, N.W., KENNESAW, GEORGIA 30144
               (Address of principal executive office) (zip code)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (770) 419-3355

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          (Former name or former address, if changed since last report)
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     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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SECTION 1 - REGISTRANT'S BUSINESS AND OPERATIONS ITEM 1.01 ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT. On February 8, 2005, Cryolife, Inc. ("Cryolife") and its subsidiaries entered into a credit agreement with Wells Fargo Foothill, Inc. The agreement created a revolving credit facility in an aggregate amount equal to the lesser of o $15.0 million that includes a letter of credit subfacility up to an aggregate $2.0 million; or o a borrowing base determined in accordance with the terms of the credit agreement. For further information on the credit agreement, please refer to Section 2.03 of CryoLife's Form 8-K dated February 8, 2005, and filed on February 10, 2005 which is incorporated herein by reference. On September 27, 2005, Cryolife, its subsidiaries, and the lender amended the credit agreement. The main purpose of the amendment was to provide specifically that the settlement of the shareholder class action suit does not constitute an event of default under the credit agreement. CryoLife reported the settlement of the shareholder class action suit on its Form 8-K dated and filed on July 28, 2005. The amendment to the credit agreement is attached hereto as Exhibit 10.2.1 and incorporated herein by reference. SECTION 2 - FINANCIAL INFORMATION SECTION 2.03 CREATION OF A DIRECT FINANCIAL OBLIGATION OR AN OBLIGATION UNDER AN OFF-BALANCE SHEET ARRANGEMENT OF A REGISTRANT. On September 27, 2005, Cryolife, Inc., its subsidiaries, and Wells Fargo Foothill, Inc. amended their February 8, 2005 credit agreement. Item 1.01 of this report describes the amendment. It is incorporated herein by reference.

SECTION 9 - FINANCIAL STATEMENTS AND EXHIBITS ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS (a) Financial statements of business acquired. (Not applicable.) (b) Pro forma financial information. (Not applicable.) (c) Shell company transactions. (Not applicable.) (d) Exhibits. Exhibit Number Description - ------- ----------- 10.2.1 "First Amendment to the Credit Agreement," signed on September 27, 2005, amends the February 8, 2005 Credit Agreement between Wells Fargo Foothill, Inc., Cryolife, Inc., and its subsidiaries

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, CryoLife, Inc. has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized. CRYOLIFE, INC. Date: September 28, 2005 By: /s/ D.Ashley Lee -------------------------------- Name: D. Ashley Lee Title: Executive Vice President, Chief Operating Officer and Chief Financial Officer

EXHIBIT INDEX Exhibit Number Description - ------- ----------- 10.2.1 "First Amendment to the Credit Agreement," signed on September 27, 2005, amends the February 8, 2005 Credit Agreement between Wells Fargo Foothill, Inc., Cryolife, Inc., and its subsidiaries

                                                                  EXHIBIT 10.2.1



                       FIRST AMENDMENT TO CREDIT AGREEMENT


     THIS FIRST AMENDMENT TO CREDIT AGREEMENT (this "Amendment"), made as of the
27th day of  September,  2005,  among  CRYOLIFE,  INC.,  a  Florida  corporation
("Parent"),  each of Parent's  Subsidiaries  identified on the  signature  pages
hereof (such  Subsidiaries,  together with Parent,  are referred to  hereinafter
each  individually as a "Borrower" and individually and  collectively,  jointly,
and severally, as the "Borrowers") and WELLS FARGO FOOTHILL,  INC., a California
corporation ("Lender"),

                              W I T N E S S E T H:

     WHEREAS,  Borrowers and Lender are parties to that certain Credit Agreement
dated as of February 8, 2005 (as amended,  restated,  supplemented  or otherwise
modified from time to time, the "Credit  Agreement";  unless  otherwise  defined
herein,  all  capitalized  terms used in this Amendment  shall have the meanings
ascribed to such terms in the Credit Agreement); and

     WHEREAS,  Borrowers  and  Lender  desire to amend the Credit  Agreement  as
hereinafter set forth;

     NOW, THEREFORE, in consideration of the premises set forth above, the terms
and conditions contained herein and other good and valuable  consideration,  the
receipt and sufficiency of which are hereby  acknowledged,  the parties agree as
follows:

     1. Amendment to Section 7.7.  Section 7.7 of the Credit Agreement is hereby
modified  and  amended  by  deleting   such  section  in  its  entirety  and  by
substituting the following therefor:

     "If one or more judgments or settlements  involving an aggregate  amount of
$1,000,000, or more (except to the extent covered by insurance pursuant to which
the insurer has accepted  liability therefor in writing and except to the extent
set forth on  Schedule  7.7 and only in an  aggregate  amount  up to the  amount
therein  indicated,)  shall be entered or filed  against  (or,  in the case of a
settlement  claim,  entered  into  by) any  Borrower  or any  Subsidiary  of any
Borrower or with respect to any of their respective  assets,  and (except in the
case of a settlement) the same is not released,  discharged,  bonded against, or
stayed  pending  appeal  before  the  earlier of 30 days after the date it first
arises  or 5 days  prior to the date on which  such  asset is  subject  to being
forfeited by the applicable Borrower or the applicable Subsidiary;"

     2. Amendment to Exhibit C-1. Exhibit C-1 to the Credit Agreement,  "Form of
Compliance  Certificate" is hereby modified and amended by deleting such exhibit
in its entirety and by substituting Exhibit C-1, attached hereto, therefor.

     3. Amendment to Schedule 7.7. The Credit  Agreement is hereby  modified and
amended by incorporating Schedule 7.7, attached hereto, thereto.

     4. No Other  Amendments.  Except  for the  amendments  expressly  set forth
above,  the text of the  Credit  Agreement  and all other Loan  Documents  shall
remain  unchanged and in full force and effect.  Each Borrower  acknowledges and
expressly  agrees that Lender  reserves the right to, and does in fact,  require
strict compliance with all terms and provisions of the Credit Agreement.

     5. Conditions of Effectiveness. This Amendment shall become effective as of
the date hereof when, and only when, Lender shall have received:

     (a) counterparts of this Amendment duly executed by each Borrower; and


(b) such other information, documents, instruments or approvals as Lender or Lender's counsel may require. 6. Representations and Warranties of Borrowers. Each Borrower represents and warrants as follows: (a) Each Borrower is a corporation duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation. (b) The execution, delivery and performance by each Borrower of this Amendment are within such Borrower's corporate powers, have been duly authorized by all necessary corporate action and do not (i) contravene such Borrower's charter or by-laws, or (ii) violate the law or any material contractual restriction binding on or affecting such Borrower. (c) No authorization, approval or other action by, and no notice to or filing with, any governmental authority or regulatory body is required for the due execution, delivery and performance by any Borrower of this Amendment. (d) Each representation or warranty of each Borrower set forth in the Credit Agreement is hereby restated and reaffirmed as true and correct on and as of the date of this Amendment, and after giving effect to this Amendment, as if such representation or warranty were made on and as of the date of, and after giving effect to, this Amendment (except to the extent that any such representation or warranty expressly relates to a prior specific date or period and except to the extent of changes in facts or circumstances permitted by the terms of the Credit Agreement). (e) This Amendment constitutes the legal, valid and binding obligation of each Borrower, enforceable against such Borrower in accordance with its terms. (f) No Default or Event of Default is existing. 7. Reference to and Effect on the Loan Documents. (a) Upon the effectiveness of this Amendment, on and after the date hereof each reference in the Credit Agreement to "this Agreement," "hereunder," "hereof" or words of like import referring to the Credit Agreement, and each reference in the other Loan Documents to "the Credit Agreement," "thereunder," "thereof" or words of like import referring to the Credit Agreement, shall mean and be a reference to the Credit Agreement as amended hereby. (b) Except as specifically amended above, the Credit Agreement and all other Loan Documents, are and shall continue to be in full force and effect and are hereby in all respects ratified and confirmed. No Borrower has any knowledge of any challenge to Lender's claims arising under the Loan Documents or the effectiveness of the Loan Documents. (c) The execution, delivery and effectiveness of this Amendment shall not, except as expressly provided herein, operate as a waiver of any right, power or remedy of Lender under any of the Loan Documents, nor constitute a waiver of any provision of any of the Loan Documents. This Amendment shall not constitute a modification of the Credit Agreement or a course of dealing with Lender at variance with the Credit Agreement such as to require further notice by Lender to require strict compliance with the terms of the Credit Agreement and the other Loan Documents in the future, except as expressly set forth herein. 8. Costs and Expenses. Borrowers, jointly and severally, agree to pay on demand all reasonable costs and expenses in connection with the preparation, execution, delivery, administration, modification and amendment of this Amendment and the other instruments and documents to be delivered hereunder, 2

including, without limitation, the reasonable fees and out-of-pocket expenses of counsel for Lender with respect thereto and with respect to advising Lender as to its rights and responsibilities hereunder and thereunder. 9. Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of Georgia without regard to conflict of laws principles of such state. 10. Loan Document. This Amendment shall be deemed to be Loan Documents for all purposes. 11. Counterparts. This Amendment may be executed by one or more of the parties hereto on any number of separate counterparts, each of which shall be deemed an original and all of which, taken together, shall be deemed to constitute one and the same instrument. Delivery of an executed counterpart of this Amendment by facsimile transmission or by e-mail transmission of an adobe file format document (also known as a PDF file) shall be as effective as delivery of a manually executed counterpart hereof. [Remainder of page intentionally left blank] 3

IN WITNESS WHEREOF, the parties hereto have caused their respective duly authorized officers or representatives to execute and deliver this Amendment as of the day and year first written above. CRYOLIFE, INC., a Florida corporation, as a Borrower By: /s/ D.A. Lee ----------------------------- Title: EVP, COO & CFO ----------------------------- CRYOLIFE TECHNOLOGY, INC., a Nevada corporation, as a Borrower By: /s/ D.A. Lee ----------------------------- Title: V.P. Finance ----------------------------- AURAZYME PHARMACEUTICALS, INC., a Florida corporation, as a Borrower By: /s/ D.A. Lee ----------------------------- Title: V.P. Finance & CFO ----------------------------- WELLS FARGO FOOTHILL, INC., a California corporation, as Lender By: /s/ ----------------------------- Title: Vice President ----------------------------- 4

EXHIBIT C-1 FORM OF COMPLIANCE CERTIFICATE [on Parent's letterhead] To: Wells Fargo Foothill, Inc. 1000 Abernathy Road, N.E., Suite 1450 Atlanta, GA 30328. Attn: Business Finance Division Manager Re: Compliance Certificate dated _________________ Ladies and Gentlemen: Reference is made to that certain CREDIT AGREEMENT (the "Credit Agreement") dated as of February 8, 2005, as modified by that certain First Amendment to Credit Agreement dated as of September ___, 2005 by and among WELLS FARGO FOOTHILL, INC., a California corporation, (together with its successors and assigns, "Lender"), CRYOLIFE, INC. ( "Parent"), and each of its Subsidiaries party thereto. Capitalized terms used in this Compliance Certificate have the meanings set forth in the Credit Agreement unless specifically defined herein. Pursuant to Schedule 5.3 of the Credit Agreement, the undersigned officer of Parent hereby certifies that: 1. The financial information of Parent and its Subsidiaries furnished in Schedule 1 attached hereto, has been prepared in accordance with GAAP (except for year-end adjustments and the lack of footnotes), and fairly presents in all material respects the financial condition of Parent and its Subsidiaries. 2. Such officer has reviewed the terms of the Credit Agreement and has made, or caused to be made under his/her supervision, a review in reasonable detail of the transactions and condition of Parent and its Subsidiaries during the accounting period covered by the financial statements delivered pursuant to Schedule 5.3 of the Credit Agreement. 3. Such review has not disclosed the existence on and as of the date hereof, and the undersigned does not have knowledge of the existence as of the date hereof, of any event or condition that constitutes a Default or Event of Default, except for such conditions or events listed on Schedule 2 attached hereto, specifying the nature and period of existence thereof and what action Parent and its Subsidiaries have taken, are taking, or propose to take with respect thereto. 4. The representations and warranties of Parent and its Subsidiaries set forth in the Credit Agreement and the other Loan Documents are true and correct in all material respects on and as of the date hereof (except to the extent they relate to a specified date), except as set forth on Schedule 3 attached hereto. 5. Parent and its Subsidiaries are in compliance with the applicable covenants contained in Section 6.16 of the Credit Agreement as demonstrated on Schedule 4 hereof. In addition, if the covenant being tested is solely Section 6.16(a), Schedule 4 also includes a calculation of EBITDA, the BioGlue Gross Margin and an indication of whether Excess Availability fell below the amount set forth in Section 6.16(b)(iii) of the Credit Agreement on any day during the preceding fiscal quarter.

IN WITNESS WHEREOF, this Compliance Certificate is executed by the undersigned this _____ day of _______________, 2005. CRYOLIFE, INC. By: --------------------------- Name: ------------------------------- Title: --------------------------- CRYOLIFE TECHNOLOGY, INC. By: --------------------------- Name: ------------------------------- Title: --------------------------- AURAZYME PHARMACEUTICALS, INC. By: --------------------------- Name: ------------------------------- Title: ---------------------------

SCHEDULE 1 FINANCIAL INFORMATION

SCHEDULE 2 DEFAULT OR EVENT OF DEFAULT

SCHEDULE 3 REPRESENTATIONS AND WARRANTIES

SCHEDULE 4 FINANCIAL COVENANTS 1. Average Excess Availability plus Qualified Cash for the fiscal quarter ended __________, 200_, is $__________, which [IS/IS NOT] greater than or equal to the amount set forth in Section 6.16(a) of the Credit Agreement. 2. a. MINIMUM EBITDA. Parent's and its Subsidiaries' EBITDA, measured on a quarter-end basis, for the twelve month period ending _________, 200_ is $______________, which amount [is/is not] greater than or equal to the amount set forth in Section 6.16(b)(i) of the Credit Agreement for the corresponding period. b. MINIMUM BIOGLUE GROSS MARGIN. Parent's and its Subsidiaries' BioGlue Gross Margin, measured on a fiscal quarter-end basis, for the twelve month period ending _________, 200_ is ___%, which [is/is not] greater than or equal to the amount set forth in Section 6.16(b)(ii) of the Credit Agreement for the corresponding period. c. EXCESS AVAILABILITY. Parent's and its Subsidiaries' Excess Availability plus Qualified Cash for every day in the fiscal quarter ending ___________, 200_ [did/did not] exceed the amount set for in Section 6.16(b)(iii) of the Credit Agreement.

Schedule 7.7 Judgments and Settlements 1. In re CryoLife, Inc. Securities Litigation. United States District Court, Northern Division of Georgia, Atlanta Division. (Civil Action No. 1:02-CV-1868 BBM). A Stipulation of Settlement to be entered into between "Lead Plaintiffs", Pete and Alison Hilbig, Richard Lippe and Stanley R. Levine, on behalf of themselves and each of the class members and defendants CryoLife, Inc., Steve G. Anderson, Albert E. Heacox, David Ashley Lee, and James C. Vander Wyk. An amount not to exceed $23,250,000 in the aggregate (with not less than $11,000,000 covered by insurance with respect to which the insurers have accepted liability). So long as no Change of Control would be caused thereby, CryoLife, Inc. has the option of funding $3,750,000 of the settlement with CryoLife common stock or cash.