UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 4
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
( ) Check this box if no longer subject to Section 16.
Form 4 or Form 5 obligations may continue. See Instructions 1(b).
1. Name and Address of Reporting Person
ANDERSON, STEVEN G.
1655 Roberts Boulevard, NW
Kennesaw, GA  30144
USA
2. Issuer Name and Ticker or Trading Symbol
CRYOLIFE, INC.
CRYL
3. IRS or Social Security Number of Reporting Person (Voluntary)

4. Statement for Month/Year
December 1999
5. If Amendment, Date of Original (Month/Year)

6. Relationship of Reporting Person(s) to Issuer (Check all applicable)
(X) Director ( ) 10% Owner (X) Officer (give title below) ( ) Other
(specify below)
President, CEO and Chairman
7. Individual or Joint/Group Filing (Check Applicable Line)
(X) Form filed by One Reporting Person
( ) Form filed by More than One Reporting Person

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Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned                                                 |
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1. Title of Security       |2.    |3.    |4.Securities Acquired (A)         |5.Amount of        |6.Dir |7.Nature of Indirect       |
| Transaction |  or Disposed of (D)              |  Securities       |ect   |  Beneficial Ownership     |
|      |      |                                  |  Beneficially     |(D)or |                           |
|      |    | |                  | A/|           |  Owned at         |Indir |                           |
| Date |Code|V|    Amount        | D |    Price  |  End of Month     |ect(I)|                           |
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Common Stock               |12/6/9|J (1| |27,012 shares     |A  |3.85       |1,034,112          |D     |                           |
|9     |)   | |                  |   |           |                   |      |                           |
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|      |    | |                  |   |           |105,333            |I     |Spouse                     |
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Table II -- Derivative Securitites Acquired, Disposed of, or Beneficially Owned                                                   |
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1.Title of Derivative |2.Con-  |3.   |4.    |5.Number of De |6.Date Exer|7.Title and Amount  |8.Price|9.Number    |10.|11.Nature of|
Security            |version |Transaction | rivative Secu |cisable and|  of Underlying     |of Deri|of Deriva   |Dir|Indirect    |
|or Exer |     |      | rities Acqui  |Expiration |  Securities        |vative |tive        |ect|Beneficial  |
|cise    |     |      | red(A) or Dis |Date(Month/|                    |Secu   |Securities  |(D)|Ownership   |
|Price of|     |      | posed of(D)   |Day/Year)  |                    |rity   |Benefi      |or |            |
|Deriva- |     |      |               |Date |Expir|                    |       |ficially    |Ind|            |
|tive    |     |      |           | A/|Exer-|ation|   Title and Number |       |Owned at    |ire|            |
|Secu-   |     |    | |           | D |cisa-|Date |   of Shares        |       |End of      |ct |            |
|rity    |Date |Code|V|  Amount   |   |ble  |     |                    |       |Month       |(I)|            |
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Incentive Stock Option|3.85    |12/6/|J (1| |27,012     |A  |(2)  |12/16|Common Stock|27,012 |N/A    |0           |D  |            |
|        |99   |)   | |           |   |     |/99  |            |       |       |            |   |            |
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|        |     |    | |           |   |     |     |            |       |       |            |   |            |
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Explanation of Responses:
(1)  This option was exercised under old Rule 
16b-3.
(2) Option has fully 
vested.
SIGNATURE OF REPORTING PERSON
STEVEN G. ANDERSON
DATE
December 10, 1999